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Research work

The scientific program of the State Medical Institution of the Moscow State Medical Center named after A. S. Loginov is part of the program of the Moscow State Medical Center "Scientific Support of the capital's Healthcare" for 2020 – 2022.

The program of research work (R & D) of the State Budgetary Institution of the Moscow State Scientific Research Center named after A. S. Loginov DZM, approved by the DZM on December 12, 2019, included 12 complex topics:

 

Topic #1: Motor-secretory and morphological changes in diseases of the esophagus and stomach 

Department-initiator of research: Department of Pathology of the upper digestive tract

Head of the research topic: D. M. N. Bordin D. S.

Departments co-executors: Department of Diagnostic Endoscopy, Operative Endoscopy, Department of Pathomorphology, Laboratory of Scientific and Diagnostic Research, Department of High-tech Endoscopy and Surgical Endoscopy, Laboratory of Clinical Psychology, X-ray Department, Department of Endocrine and Metabolic Surgery, Center for Personalized Medicine, Department of Hematology.

The aim of the study: cancer prevention based on the study of precancerous diseases of the esophagus and stomach and improving the effectiveness of therapy in patients with impaired motor function of the esophagus, based on the study of etiopathogenetic mechanisms. 

 

Topic No. 2: Improving the diagnosis and treatment of chronic pancreatic diseases

Department-initiator of research : Department of Pathology of the Pancreas and Biliary Tract

Head of the research topic: D. M. N. Bordin D. S.

Departments co-executors: center for Personalized Medicine, Laboratory of Nutritionology, Department of Innovative Surgery, Department of Radiation Methods of Diagnosis and Treatment, Clinical and diagnostic Laboratory, Laboratory of Scientific and diagnostic Research, Laboratory of Preclinical Research, Laboratory of Pathomorphology

The purpose of the study: To develop an algorithm for differential diagnosis of chronic pancreatitis and pancreatic cancer and the basic principles of therapy for accompanying patients with pancreatic cancer for their application in practical health care.

 

Topic #3: Development of diagnostic and prognostic criteria for the course and outcomes of autoimmune liver diseases

Department-initiator of research : Department of Hepatology (Department of Liver Diseases)

Head of the research topic: Doctor of Medical Sciences E. V. Vinnitskaya

Departments co-executors: laboratory of Scientific and Diagnostic Research, Laboratory of Pathomorphology, Laboratory of Clinical Immunology, Laboratory of Genetics, Department of Diagnostic Endoscopy, Department of Radiation Diagnostic Methods).

Objective: to develop criteria that determine the progression and outcomes of autoimmune liver diseases depending on the form, activity, stage of the disease, therapeutic approaches and initial characteristics of patients.

 

Topic # 4: Prospects for improving the effectiveness of treatment and the quality of life of patients with intestinal pathology

Initiator of research : Department of Intestinal Pathology (Department of IBD Treatment, Department of Non-inflammatory Intestinal Pathology, Laboratory of Functional Diagnostics of Intestinal Diseases)

Head of the research topic: Prof. Parfenov A. I. 

Office co-executors: Department of neurology, division of diagnostic endoscopy, diagnostic laboratory, laboratory of pathology, Department of pathological anatomy, laboratory of clinical psychology, laboratory of preclinical research, laboratory of drug metabolism, laboratory of fundamental research, center of anesthesiology and intensive care, Department of ultrasound diagnostics, Department of Hematology, center for personalized medicine, laboratory of clinical immunology, Department of Coloproctology, Department of vascular surgery, research Department of rheumatology.

Objective: to improve the effectiveness of treatment and quality of life in patients with ulcerative colitis, Crohn's disease, celiac disease and functional bowel diseases. 

 

Topic #5: Hormonal, metabolic, and clinical features of endocrine diseases

Department-initiator of research : Department of Endocrine and Metabolic Diseases

Head of the research topic: Prof. Mkrtumyan A.M. 

Departments co-executors: center for Endocrine and Metabolic Surgery, Department of Innovative Surgery, Department of Radiation Methods of Diagnosis and Treatment, Department of Diagnostic Endoscopy, Laboratory of Pathomorphology, Center for Personalized Medicine, Department of Pathology of the upper digestive Tract, Laboratory of Scientific and Diagnostic Research, Laboratory of Drug Metabolism.

The purpose of the study: Improvement of methods of diagnostics, prevention and treatment of endocrine diseases.

 

Topic #6: The choice of treatment tactics when changing the tumor phenotype during metastasis 

Department-initiator of research : Chemotherapeutic Department

Head of the research topic: MD, Prof. Zhukova L. G.

Departments co-executors: department of High-tech Surgery, Department of Clinical Mammology and Reconstructive Plastic Surgery of the Breast, Department of Coloproctology, Center for Personalized Medicine, X-ray Department, Center for Endocrine and Metabolic Surgery, Department of Diagnostic Endoscopy, Oncosurgical Department of Skin and Soft Tissue Tumors.

Objective: to optimize drug therapy in patients with breast, pancreatic, lung, colorectal cancer, and neuroendocrine tumors of the gastrointestinal tract, taking into account changes in the phenotype and genotype of the tumor during metastasis.

 

Topic No. 7: Modern technologies for the diagnosis and treatment of surgical and oncological diseases of the hepatopancreatobiliary zone 

Department-initiator of research : Department of Hepatopancreatobiliary Surgery

Head of the research topic: MD. Efanov M. G.

Departments co-executors: Department of Radiation Diagnostic Methods, Laboratory of Radioisotope Diagnostics, Department of Prevention and Treatment of Bacterial Infections

The aim of the study: to improve the immediate and long-term results of treatment of patients with surgical and oncological diseases of the hepatopancreatobiliary zone due to the comprehensive introduction of modern technologies at the stages of preparation and implementation of radical intervention

 

Topic No. 8 Laparoscopic and robotic technologies in the treatment of benign and malignant diseases of the stomach and pancreas

Department-initiator of research : Department of Innovative Surgery, Department of High-tech Surgery and Endoscopy

Head of the research topic: Prof. Izrailov R. E.

Departments co-executors: laboratory of Nutritionology, Laboratory of Pathomorphology

The purpose of the work: To investigate the possibilities of minimally invasive technologies in the surgical treatment of benign and malignant diseases of the stomach and pancreas in patients with preliminary correction of metabolic disorders in accordance with a single algorithm.

 

Topic # 9: Squamous cell carcinoma of the head and neck: treatment tactics and reconstruction methods 

Department-initiator of research : Department of Head and Neck Tumors 

Head of the research topic: M. A. Kropotov, MD 

Departments co-executors: Department of Operative Endoscopy, Department of Ultrasound Diagnostics, Department of Pathomorphology, X-ray Department, Clinical and Diagnostic Laboratory 

The purpose of the study: Improving the results of treatment of patients with squamous cell carcinoma of the head and neck organs by selecting the most rational modes of complex and combined treatment, optimizing the types and volumes of surgical interventions, determination.

 

Topic #10: Improvement of surgical methods for the treatment of diseases of the colon, anal canal and perianal area

Department-initiator of research : Department of Coloproctology

Head of the research topic: Candidate of Medical Sciences Danilov M. A.

Departments co-executors: Department of Operative Endoscopy, Department of Ultrasound Diagnostics, Department of Treatment of Inflammatory Bowel Diseases, Department of Pathomorphology

Objective: to improve the results of surgical treatment of diseases of the colon, anal canal and perianal area.

 

Topic #11: Endoscopic diagnosis and treatment of diseases of the hepatopancreatobiliary zone

Department-initiator of research : Endoscopy Department

Head of the research topic: Doctor of Medical Sciences Shishin K. V.

Departments co-executors: clinical and diagnostic laboratory, Department of Pathomorphology, Department of Radiation Methods of Diagnosis and Treatment, X-ray Department

The purpose of the study: Improve the results of diagnosis and surgical treatment of diseases of the hepatopancreatobiliary zone using endoscopic technologies

 

Topic No.12: Auxiliary ventilation for robot-assisted and laparoscopic interventions

Department-initiator of research : Department of Anesthesiology-Intensive Care Unit No. 1

Head of the research topic: Doctor of Medical Sciences Subbotin V. V.

Departments co-executors: Department of Urology, Department of Gynecology, Department of Clinical and Laboratory Scientific Research.

The purpose of the study: To improve the quality of anaesthetic aid for long-term laparoscopic and robot-assisted interventions in the pelvic area and / or lower abdominal cavity by developing a protocol for intraoperative assisted lung ventilation.

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