Celiac disease (gluten-sensitive celiac disease, gluten enteropathy) – a disease based on autoimmune inflammation of the small intestine mucosa in people with a genetically determined sensitivity to gluten – a protein found in wheat, rye and barley.
Inflammation leads to the development of atrophy of the villi of the small intestine mucosa, leading to chronic diarrhea, malabsorption syndrome or the appearance of extra-intestinal symptoms (anemia, osteoporosis, miscarriage, etc.).
Previously, it was believed that celiac disease is quite rare — with a frequency of 1:3000. Modern population studies have shown that the gene responsible for the predisposition to celiac disease is quite common, and the disease itself is present in about 1% of the population.
Typical celiac disease with severe malabsorption is indeed rare. In the overwhelming majority, extra-intestinal manifestations are detected: iron deficiency anemia, aphthous stomatitis, Duhring's dermatitis, osteoporosis, small stature, delayed sexual development, infertility, type 1 diabetes, etc.For every identified case, there are 7 undiagnosed cases!
In the department of intestinal Pathology of the MCSC, a comprehensive examination is carried out to diagnose celiac disease and differentiate such conditions as gluten intolerance and gluten allergy.
The gold standard in the diagnosis of celiac disease is the histological examination of biopsiesobtained from the distal duodenum and jejunum.
In the laboratory of pathomorphology, Professor S. G. Homerika can provide a qualified histological opinion on the biopsy material obtained during esophagogastroduodenoscopy, as well as consult ready-made histological preparations made in other medical institutions.