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Neuroendocrine tumors

Keywords: NEO, insulinoma, gastrinoma, glucagonoma, neurinoma, Vipoma, somato-statinoma, neuroblastoma, paraganglioma.

Neuroendocrine tumors (NEOS) is the unifying name for a heterogeneous group of tumors that develop from neuroendocrine cells. Neuroendocrine cells produce bioactive substances that have various regulatory functions. Since these cells are located in so many places in the body, NEOS have a variety of localization, different growth patterns, clinical signs, etc. NEOS are both benign and malignant. The most common of them are insulinoma, gastrinoma, glucagonoma, neurinoma.

Along with hormone-active neuroendocrine tumors that produce bioactive substances known to us, there are so-called hormone-inactive tumors that also produce something, but these substances are not yet determined.

Who is at risk:

  • women of reproductive age and postmenopausal women 
  • men aged 45 and over
  • patients with a complicated family history of cancer. 

You can suspect the disease if the following symptomsoccur . 

With hormone-active tumors

  • hot flashes, low blood pressure, stool disorders, abdominal pain;
  • loss of appetite, nausea and diarrhea, weight loss with swelling of the face and limbs;
  • increased sweating, trembling of the limbs, blurred vision, attacks of confused consciousness, convulsions, lesions of the scalp and trunk;
  • single and multiple small ulcers in various parts of the gastrointestinal tract;
  • diabetes, stomatitis, glossitis, depression.

With hormone-inactive tumors, there are no specific clinical manifestations and complaints, but the risk of malignancy persists.

In the diagnosis of neuroendorkin tumors, in addition to radiation methods (ultrasound, CT, MRI), laboratory determination of bioactive substances produced by neuroendocrine cells in the blood/urine is very important.In the Moscow Clinical Scientific and Practical Center named after A. S. Loginov, therapeutic tactics are determined in each specific case at a consultation (meeting) of all necessary specialists, primarily endocrinologists, oncologists and surgeons.

In most cases, in the absence of contraindications, surgical treatment is indicated at the first stage. In our center, modern laparoscopic operations are performed, including with the use of the DaVinci robot, which allows you to remove the tumor while preserving the organ in which it was located.

In some cases, treatment begins with drug therapy, and then, depending on its results, the need for surgery is discussed again. Currently, the Center employs highly qualified endocrinologists, oncologists and surgeons who have the necessary modern means of treatment.

Do not delay your visit to the specialists of our Center. This will help to diagnose the disease in a timely manner and choose the right treatment tactics. Doctors of the Department of High-tech Surgery and Surgical Endoscopy of the State Medical Institution of the Moscow State Medical Center named after A. S. Loginov DZM are always ready to help you.

GBUZ Moscow Clinical Scientific Center named after Loginov MHD