Autoimmune crossover syndrome

Autoimmune crossover syndrome is a variant form of classic autoimmune diseases: autoimmune hepatitis( AIH), primary biliary cholangitis (PBH), primary sclerosing cholangitis (PSC).

Cross syndrome refers to the presence in one patient of clinical, biochemical, serological and / or histological signs characteristic of both autoimmune hepatitis and autoimmune cholestatic disease. 

The cause of autoimmune crossover syndrome, as well as other autoimmune diseases, remains unknown. 

There is a hereditary predisposition to AIG, PBH, PSC. 

It is assumed that individuals with a genetic predisposition under the influence of provoking factors (viral infection, taking certain medications, sometimes for no apparent reason) have disorders in the immune system, as a result of which their own proteins are perceived as foreign, against which the immune system begins to produce antibodies (autoantibodies) and damage to liver tissue occurs.

Symptomsthat allow you to suspect a disease.

The clinical manifestations of autoimmune junction syndrome can be very diverse and often not specific: from the absence of symptoms or slight general weakness, discomfort in the right hypochondrium to the presence of severe itching, fatigue and progressive general weakness, the appearance of muscle and joint pain, fever. 

Some patients may be completely asymptomatic for a long time at the initial stages, and then changes in the biochemical parameters of the blood of the hepatic profile are detected quite accidentally during routine medical examinations. 

In other patients, the disease develops acutely: with an increase in body temperature, jaundice of the sclera and skin, itching, nausea.  

What tests do you need to pass in order to establish this diagnosis? 

In order to establish the diagnosis of autoimmune crossroads syndrome, as well as other autoimmune liver diseases, a comprehensive approach is required.

This is a laboratory diagnosis of a number of standard biochemical parameters of the liver (ALT, AST, GGTP, ALP, bilirubin, albumin, etc.), a general blood test. However, most often, a number of specific diagnostic tests are required to detect autoimmune antibodies. Patients necessarily need to perform instrumental examinations: ultrasound examination of the abdominal organs, often-magnetic resonance cholangiopancreatography (MRCPG). But most often, for a correct diagnosis, it is necessary to conduct a liver biopsy, followed by a morphological examination, which will allow you to establish a complete diagnosis and prescribe adequate therapy.

In the Moscow Clinical Scientific and Practical Center named after A. S. Loginov, the diagnosis and treatment of cirrhosis of the liver is carried out in the department of chronic liver diseases by gastroenterologists-hepatologists, as well as by researchers of the Center for diagnosis and treatment of liver diseases and the Department of Hepatology

Do not delay your visit to the specialists of our Center. This will help to diagnose the disease in a timely manner and choose the right treatment tactics.

GBUZ Moscow Clinical Scientific Center named after Loginov MHD