Online consultations with MCSC doctors n. a. A. S. Loginov

Depression and pain

In recent years, the relationship between pain and depression has been actively studied.

According to some data, up to 50% of cases of depression are accompanied by complaints of pain, the localization and nature of which may be different. At the same time, the risk of developing a depressive disorder in people with chronic pain is much higher than in the population.

According to various data, up to 85% of people who experience chronic pain (as a stress factor) also suffer from depression of varying severity.

It is known that depression is a concomitant disease in chronic pain. On the other hand, pain can be one of the manifestations of depression (abdominal pain, headaches, muscle pain-are the most common).

However, data on the overall biological nature of these changes are of interest:

Neurotransmitter systems involved in the regulation of affective background, sleep, anxiety levels, and stress responses are also part of the analgesic endogenous system:

  • Serotonin
  • Norepinephrine
  • Endorphins

It was also revealed that in chronic pain, the same brain structures are involved that have been proven to be involved in mood regulation: the prefrontal cortex, hippocampus, thalamus, and amygdala.




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