Fibromax is a non-traumatic diagnostic method, a unique alternative to liver biopsy. For the analysis, blood is simply taken from a vein. The final result is calculated using a proprietary algorithm, a special software method.
The Fibromax test is a comprehensive analysis. It includes the following biochemical parameters of the blood:
- alanine aminotransferase-abbreviated ALT;
- aspartate aminotransferase-abbreviated as AST, AsAT, AST;
- gamma-glutamyltransferase-abbreviated GGTP;
- aliprotein A1;
- total cholesterol;
— blood glucose;
- total bilirubin.
The analysis takes into account the weight, gender, and height of the patient.
Five calculated test algorithms:
- FibroTest (FibroTest) — liver fibrosis is detected.
- ActiTest-viral necroinflammatory activity is evaluated.
- SteatoTest (SteatoTest) – steatosis is diagnosed.
- NashTest-indicates the presence of non-alcoholic steatohepatitis.
- Ashtest (AshTest) – shows the presence of alcoholic steatohepatitis.
Indications for use
The test is prescribed if the patient has:
- Chronic hepatitis B and C;
- Steatosis (Fatty hepatosis)
- Steatohepatitis (alcoholic and non-alcoholic);
- High cholesterol;
- Diabetes mellitus.
Preparing for analysis
It is advisable to start preparing two days before the test. Basic rules:
- Blood is given only on an empty stomach.
- Two days before the test, you can not eat fried, smoked, fatty food, alcohol.
- Physical activity should be restricted 12 hours before the test.
- Before passing the analysis, you should exclude smoking.
The test is not done when:
- Extrahepatic cholestasis (Mechanical jaundice)
- Acute hemolysis;
- Hepatitis A, B, C, D, E in the acute stage, drug-induced hepatitis;
Decoding the results
All test results are in the range from zero to one. The indicator depends on the severity of the disease (the level of ActiTest activity). The results were transferred to the METAVIR system: FibroTest F0 — F4, ActiTest A0 – A3, SteatoTest S0 – S3 (4), NashTest N0 — N2, AshTest H0 — H3.
For a more convenient visual interpretation, the test result is accompanied by a color graphic image. Which is quite convenient. Colors from green to red.
Now let's take a closer look at each of the tests:
Interpretation of FibroTest results
- Green color-indicates the minimum stage of fibrosis or its absence;
- Orange color-this color indicates moderate fibrosis;
- Red color-this color means pronounced fibrosis.
Scheme of translation of FibroTest results in stages on three scales of histological indices:
Interpreting ActiTest results
- Green - indicates that there is minimal or no activity at all;
- Orange color-indicates a moderate degree of activity;
- Red color – pronounced activity.
Interpreting SteatoTest results
— S0 steatosis is absent;
- S1 steatosis is minimal, less than 5% of hepatocytes with steatosis;
- S2 moderate steatosis, 6% - 32% of hepatocytes with steatosis;
- S3-S4 steatosis is pronounced, 33%-100% of hepatocytes with steatosis.
Interpreting NashTest results
N0-green color, no NASH (non-alcoholic steatohepatitis);
N1-orange color, NASG is possible;
Interpretation of AshTest results
- H0-ASG (alcoholic steatohepatitis) missing (green);
- H1-ASG is minimal (green);
- H2-ASG moderate (orange);
- H3-ASG pronounced (red).
Re-assigning the test
Chronic hepatitis: the frequency of passing the test every six months.
If the patient is prescribed antiviral therapy, the test is performed before the start of therapy, and then after it ends.
Some drugs used in antiviral therapy have an effect on blood counts. Therefore, the test is not done during the therapy period.